How Intrauterine Infusion Helps to Thicken the Endometrium

How Intrauterine Infusion Helps to Thicken the Endometrium

An embryo may not be able to implant or thrive if a woman’s endometrium is not sufficiently thickened. Intrauterine Infusion using Platelet Rich Plasma (PRP) may correct a woman’s constantly thin uterine lining. PRP infusion has been found to promote uterine lining thickening and increase the chances of a healthy pregnancy.

Intrauterine Infusion

Intrauterine Infusion is a last resort treatment before recommending gestational surrogacy. A recent study was conducted to evaluate the effectiveness of injecting a woman’s Platelet Rich Plasma into her uterus (PRP) as a method of treating a poor quality endometrial lining. This procedure is known as Intrauterine Infusion.

  • Ten patients undergoing FET cycles participated in the study
  • Each patient had a history of inadequate endometrial thickening
  • Intrauterine Infusion of the patient’s own PRP was performed
  • Endometrial thickness was then assessed and determined to have improved
  • Five of the ten patients became pregnant (50% success rate)

The study concluded that PRP was effective for enhancing endometrial lining thickness in patients suffering from a constantly thin endometrium.

The Endometrium

The lining of a woman’s uterus is the endometrium. The line of a woman’s uterus must be sufficiently thickened in order for an embryo to implant and grow. Adequate thickening of the uterine lining is one of the main factors in determining whether or not a successful pregnancy is achieved through a fresh IVF cycle or a frozen embryo transfer (FET).

Intrauterine Infusion

Intrauterine Infusion may be a last resort treatment for infertility before a couple opts for surrogacy.

PRP Therapy is a good source for growth factors that promote:

  • Regeneration of cells
  • Improvement of white blood cell function
  • Augmentation of angiogenesis and matrix deposition

PRP Therapy has been studied since the year 2000. PRP Therapy is commonly used in other areas of medicine.

  • Orofacial surgery
  • Orthopedic surgery
  • Ophthalmologic surgery
  • Healing of athletic injuries
  • Plastic surgery procedures
  • Injection in vaginal area for women with low sex drive

Embryo Implantation Failure vs. Recurrent Pregnancy Loss

Many patients suffering from infertility don’t realize the difference between embryo implantation failure and recurrent pregnancy loss. Regardless of why a pregnancy does not occur – or why one fails – couples suffering from either of these conditions need empathy and understanding. Through an accurate diagnosis of the root cause of your inability to conceive – or maintain a pregnancy – successful treatment is available from Dr. Hugh Melnick.

  • Embryo Implantation Failure – the inability of an embryo to attach to the lining of the uterus
  • Recurrent Pregnancy Loss – an embryo fails to thrive after having attached to the lining of the uterus

Embryo Implantation Failure

Most failed implantations are due to poor embryo quality. Good quality embryo implantation failure can occur due to poor endometrial receptivity or hostile uterine conditions. Embryo implantation dysfunction prevents an embryo from properly attaching to the uterine lining.

Implantation dysfunction is caused by:

  • Constantly thin endometrium
  • Uterine surface lesions

Constantly Thin Endometrium

Pregnancy and live birth success rates rise substantially with increased endometrial thickness – independent of patient age and embryo quality factors.

  • Embryo implantation rates are highest when the endometrial lining has a thickness of 9 mm or greater
  • An endometrial lining thickness of 7 mm is adequate for embryo implantation
  • A constantly thin endometrial lining – 5 mm – is cause for concern of a potential failed cycle
  • Less than 5 mm – there is almost no chance of a pregnancy

How to Know if You’re a Candidate

Prospective candidates for Intrauterine Infusion are:

  • Women who want to carry their own baby in lieu of gestational surrogacy
  • Women who have failed multiple IVF treatments after having produced high quality embryos
  • Women diagnosed with unexplained infertility
  • Women having suffered from recurrent miscarriages

Your initial consultation to find out if you are a candidate for Intrauterine Infusion can be conducted with the Doctor via telephone, Skype or FaceTime.

Fertility Doctor Specializing in Intrauterine Infusion

Schedule your initial consultation with Dr. Hugh Melnick at Advanced Fertility Services by calling 212.369.8700 – or – clicking the icon below.

Speak to Dr. Melnick